"[It] possesses the most wide-ranging benefits for human health and wellness of any plant yet discovered."
-Dr. Jialiu Li
A census taken of remote mountain villages in the Guizhou, Guangxi and Sichuan provinces of China revealed unusual numbers of people living to be over 100 years old.
Turns out these centenarians are making their morning and evening tea from a wild vine rather than traditional green tea leaves.
But here’s what really caught my attention:
This "Immortality Vine" not only helps these natives live longer lives… it helps them live better, more active and more energetic lives.
These people are living in a world without access to modern health care. They don’t have corner pharmacies or health insurance.
But these centenarians don’t act like most 100-year-olds we’re used to…
They pop out of bed every morning and don’t take naps. They’re spry and agile and active… and don’t complain of uncomfortable joints or age-related stiffness.
Their minds are sharp as tacks. Their hearts are strong. They’re living past a hundred… and enjoying every minute of it!
- Superhuman levels of energy
- Lean, slim physiques
- Extremely low rates of age-related decline
The leaves from this vine contain the secret to a better, longer life!
All thanks to the tea they are drinking.
Secret Enzyme Hidden in Your Cells Regenerates the "Molecule of Life"
This powerful new ingredient may be news to the Western world, but it’s not new in China. It’s been helping people live longer, better lives for over 600 years… since the Ming Dynasty, in fact!
The villagers make this life-giving tea from a vine called Gynostemma pentaphyllum.
They knew drinking tea made with "The Immortality Vine" resulted in longer life and stronger bodies, but they didn’t know why.
But I do.
My name is Al Sears, MD, and I’ve been studying ways to increase energy levels in my patients for decades.
The mountains of China hold an ancient secret known only to a few — up till now.
When I stumbled on this vine, I realized it would make sure you never run out of energy… no matter how long you live!
You see, Gynostemma pentaphyllum stimulates the very important enzyme called AMPK in every cell of your body.1
And AMPK regenerates cAMP… what I like to call "The Molecule of Life." cAMP is where we get all our energy. Without it, you become tired and lethargic.
When you’re young, you’ve got loads of AMPK working in every cell of your body to keep you energized and your cells healthy.
But the older you get, your AMPK enzymes become less "activated."
And that’s when you see age-related conditions like increased belly fat, unhealthy blood sugar levels and other destructive factors of aging.
AMPK Offers All the Benefits of Fasting… Without Missing a Meal!
I frequently recommend intermittent fasting to my patients as an energy-producing and anti-aging therapy whose roots can be traced back to the earliest days of the human species — maybe even before that.
Fasting has the power to ward off the chronic diseases of aging and add healthy years to your life. Nature magazine tells us calorie restriction actually reduces the number of age-related disorders in mammals.2
Fasting is also scientifically proven to boost energy, vitality and longevity.
But let’s face it. Starving yourself isn’t much fun. The good news is, activated AMPK actually mimics caloric restriction in your body… which means you can enjoy all that extra energy and vitality without ever missing a meal!3
What activated AMPK does is take your own fat cells — and excess blood sugar that’s floating around in your body — and sends them directly to your cells to be burned for energy.
The results are healthy blood sugar levels… and less fat around your middle! If you’ve noticed a "spare tire" creeping up around your waist, it’s because your AMPK isn’t working as hard for you as it did when you were in your 30s.
So even if you don’t change anything in your diet or exercise level, you’re still likely to gain that unwanted weight.
Researchers at Stanford University are looking at the connection between calorie restriction and increased lifespan… with oustanding results!
In fact, they’ve shown that AMPK has to be activated in order for calorie restriction to extend lifespan and delay age-dependent decline.4
Meanwhile, at UCLA, scientists have shown that increasing the amount of AMPK in fruit flies increased their lifespans by 30% — and the flies stayed energized, healthy and active much longer as well!5
You may wonder what fruit flies have to do with you, but here’s the thing: they share 75% of the genes that cause disease with humans, so we can learn about humans by studying fruit fly genetics.
It didn’t surprise me to find out that AMPK is related to increased energy levels… because it’s also connected to the health and number of mitochondria we have.
On top of all the other things AMPK can do, it also creates new mitochondria… and eliminates cellular garbage that gathers inside old cells!
More Healthy Mitochondria = More Energy
Your cells can have anywhere from 2 to 2,500 mitochondria, depending on how much energy they need. But those mitochondria die off as you get older.
That’s why the researchers at Johns Hopkins University were able to make the link between weakness and frailty, and disappearing mitochondria.10
Right now, as you read this, you’re creating energy inside your mitochondria with the "cellular spark" known as CoQ10.
There’s a reason I’ve been studying it — and measuring it in my patients — for over 20 years.
In fact, it’s so important, it should really be considered a vitamin.
But a few years ago, I realized that while CoQ10 is essential for creating the spark inside your cell’s "power generators"… it wasn’t enough.
I needed to find a way to increase the NUMBER of power generators, or mitochondria, in your cells.
So I turned to pyrroloquinoline quinone, or PQQ — which meant a giant leap toward "eternal youth" for my patients.
Because PQQ increases and multiplies the number of mitochondria in your cells.
Together with CoQ10, it amps up your cellular energy and provides a high-voltage boost that makes every tissue, organ and system in your body run on super-charged, never-ending youthful energy.
Just like kids have.
But it still wasn’t enough…
That’s when I looked at ginseng and its energy-boosting benefits…
You see, ginseng is an adaptogen. Adaptogens are herbs that are proven to be safe, non-toxic and beneficial to you in some way.
Ginseng has been used for thousands of years to invigorate and rejuvenate.
And it was while I was researching Ginseng that I discovered "The Immortality Vine."
It did everything Ginseng could do… and a lot more!
The extract from this vine goes beyond "creating a spark" inside your mitochondria… it goes beyond creating MORE mitochondria… this extract not only controls how long you will live, but HOW WELL you will live! 11
It would mean another giant step toward "eternal life." And I’m not talking about extra years spent sitting in a nursing home or confined to bed…
I’m talking about extra years filled with the energy, stamina and the drive to do whatever you want to do!
- Take your grandchildren to Paris, or your spouse on safari? Sure!
- Put in a few more years at the career you’ve built? Or start a new business? Why not?
- Golf and tennis are great, but what about white water rafting? Or flying an ultralight? Let’s go!
- Finally get around to writing your novel or painting a masterpiece? It’s time!
- Dust off your workshop or craft room and get to work? Finally!
Because with this new discovery, there’s no limit to what you can do…
Three Energy Powerhouses Together
for the First Time
Thousands of people around the globe are already feeling stronger, more resilient and more potent thanks to the power of CoQ10 and PQQ in my popular formula, Ultra Accel…
When I heard about the almost-unbelievable amounts of energy created by this rare extract from “The Immortality Vine,” I wasted no time adding it the formula.
Now available together for the first time, the exponential energy-boosting ingredients in Ultra Accel II are more potent than we ever thought possible. Imagine waking up every day knowing the best part of your life is still ahead of you!
Wouldn’t it be great to stay out of your doctor’s office and busy enjoying life to its fullest… without an overflowing medicine cabinet!
"More Energy in 24 Hours"
"I noticed more energy within 24 hours of taking Ultra Accel. I was thrilled to have all that extra strength and endurance. Then after a few months, I ran out and within a week, all that extra energy disappeared. I didn’t realize how much it affected me until it was gone. Now, I’ll never be without Ultra Accel."
– Karyn E., West Palm Beach, Florida
"My Endurance Doubled"
"I exercise several times a week, and with Ultra Accel, my endurance doubled. I love it. There really is something about Ultra Accel that I can FEEL. It’s not just in your body either. You can feel it mentally, too. This is something I’ll be taking for a long time."
– Jerry M., Wellington, Florida
"Who’d Risk NOT Feeling Like This?"
"I’ve always had high energy levels from being physically active and into sports. [With Ultra Accel] I’ve found my energy levels to be as high or higher with less exercise. People can’t believe I turned 50 this year. I intend to keep taking Ultra Accel for the rest of my life. Who’d risk NOT feeling like this?"
– Wayne L., Sydney, Australia
As Your Mitochondria Disappear,
So Does Your Life Force
When I ran one of my first clinical studies on CoQ10, I discovered 87% of my patients had low levels. Today, CoQ10 is one of the most widely used supplements on the market. And for good reason.
When I began combining CoQ10 with PQQ, my patients began "waking up" vast stores of energy and physical strength, and feeling a bright clarity of mind for the first time in years.
Many tell me they get that "ah-ha moment" sensation when they suddenly understand what "cellular energy" really means… because they FEEL a rush of youthful energy wash through what used to be a tired, old body.
The Secret to Boundless Energy Revealed
When the power generators in your cells break down, you become old and weak and frail.
That’s why old men shuffle when they walk… it’s why they need to take afternoon naps… and it’s why they wind up sick and tired. When you lose your power generators, you become weak and helpless.
Loss and damage to your mitochondria accelerates aging. And it’s directly linked to all the horrifying problems that sneak up on you as you get older.
But mitochondria have their own supply of DNA. That means they can REPLICATE and, therefore, INCREASE their number, within a cell… if they have the right nutrients.
PQQ Triggers What We Call "Mitochondrial Biogenesis"
Mitochondrial biogenesis is a fancy way of saying PQQ activates the genes that give birth to new power generators in your cells.
Not surprisingly, it’s the "energy-hungry" organs like your heart and brain that have the most mitochondria.12,13,14
But as your mitochondria become damaged and weak, they die off, and you lose your capacity to make energy. Imagine owning a business with 2,500 employees and suddenly having to get by with just 10 or 20. You’d have to close your doors in a hurry.
The same thing happens in your cells. Lose your workforce, and suddenly your heart, brain or liver has to "close its doors." And you know what that means.
CoQ10 is a critical piece of the puzzle, because it acts as the "spark plug" inside the mitochondria. CoQ10 helps each individual mitochondria make energy.
But one of the keys to staying young is having MORE mitochondria that are healthy enough to produce energy.
Remember, the more of these power generators you have, the more you’ll feel like that energetic 5-year-old who never seems to run out of steam.
Researchers Prove PQQ Makes MORE Mitochondria
Researchers at the University of California at Davis are pioneers in the study of PQQ. Their work shows a clear connection between PQQ and the growth of new mitochondria.
In one study, published in the Journal of Nutrition, researchers fed mice a diet supplemented with PQQ, and grew a staggering number of new mitochondria in just 8 weeks.15
SOURCE: Stites T, et al. Journal of Nutrition
Have a look at this graph…
On the left, you can see the number of mitochondria BEFORE the mice were fed PQQ. And on the right, you can see what happened AFTER the mice started taking PQQ.
Lots more mitochondria!
In just 8 weeks, PQQ dramatically boosted the number of mitochondria in the cells of the mice.
This is great news for your entire body… but especially for your brain.
PQQ stimulates the natural production of nerve growth factor, which triggers the growth of new brain cells.16,17 PQQ also relieves the stress on your brain cells called excitotoxicity.18,19 This is the over-stimulation of brain cells that causes senility and loss of memory as you get older.
So, not only does PQQ create new power generators, it helps restore younger, faster brain power.
All that new energy keeps your heart young, too. PQQ is a remarkably strong antioxidant that shields the mitochondria in your heart from the stress of making all that energy.
And that’s a good thing, because mitochondria are fragile. They don’t have the same kind of protection other parts of the cell enjoy. So, PQQ’s role as "protector" of mitochondria is just as important as its ability to make new ones.
When I combined PQQ with CoQ10, amazing things started to happen.
The result was one of the first formulas in the world to successfully combine the newly discovered power of PQQ with the enhanced absorption of the high-powered CoQ10 in Accel.
You see, in 2006, I met with Dr. Tatsumasa Mae, the world’s leading CoQ10 researcher and one of the first to use the better-absorbable, more bio-available form of CoQ10, which I put in my original formula called Accel.
From that very day, my patients and readers experienced an immediate boost in energy, stamina and heart strength. At the time, I thought we had reached the limit of how much energy could be produced in your cells.
If you’re unfamiliar with this stronger form of CoQ10, have a look at what happened when it was given to a group of aging mice…
The Adventures of "Super Mouse"
Remember the old "Adventures of Superman" TV series with George Reeves?
In one episode, a scientist invents an energy pill that gives a laboratory mouse super strength similar to Superman’s — turning the ordinary mouse into "Super Mouse."
Taking this high-powered CoQ10 won’t give you super strength or super speed. But it can boost your energy by a degree you can notice and feel.
How can I be so sure?
When I had a private meeting with Dr. Mae, he showed me a videotape of the test subjects he used in an animal study of the anti-aging properties of CoQ10.
The video showed that after several months, his lab mice not taking CoQ10 all died of natural causes.
All of the untreated mice showed typical signs of oxidative stress, suffering brain and heart damage.
A second group of test mice took conventional CoQ10. They were still alive, but showed signs of aging. These mice lasted longer than the first group, but when they died, they had similar conditions.
And what I saw was nothing short of a small miracle…
The test subjects taking this form of CoQ10 were not just alive. They actually looked younger than the mice in the other groups!
They also had more energy. They were running around in their cages with all the vigor of mice half their age.
And, in spite of being "old" (for mice), they showed almost no sign of aging. After a year, the "super mice" aged 22% slower than mice taking conventional CoQ10, and 51% slower than mice taking no CoQ10.
Researchers also measured the effect of CoQ10 supplementation on stamina. They found that mice taking this super-absorbable form of CoQ10 were able to run continuously on their treadmills two and a half times longer than mice taking conventional CoQ10.
Imagine what that kind of energy could mean for you!
The Many Health Benefits of Taking Ultra Accel II
Increased energy, improved metabolic function, cell protection, better cardiovascular health and weight loss are just the tip of the iceberg when it comes to the many health benefits my patients and I experience when we take our Ultra Accel II every day.
Because now we’re breaking new ground and moving into a world of extreme energy and perpetual youth that seems to break all the rules.
I’ve combined the two blockbuster ingredients in Ultra Accel with a powerful AMPK activator that provides an exciting new energy source for your cells while preventing a whole host of age-related issues.
Here are just some of the ways Ultra Accel II can help you live longer and feel better:
- Heart health: According to the Journal of Cardiovascular Pharmacology, a number of clinical studies have found CoQ10 promotes cardiovascular health.20,21 PQQ promotes blood flow in the heart.22
- Blood sugar: An Australian study showed that patients who took CoQ10 were able to maintain normal blood sugar levels.23 AMPK improves glucose uptake in cells, supporting blood sugar within the normal range.24
- Vision: In a recent clinical trial, taking CoQ10 for a year helped people see more clearly.25
- Weight: AMPK moves excess fats into your mitochondria to be used as energy — resulting in more energy and a slimmer waistline!
- Cholesterol: AMPK promotes healthy triglyceride levels.26
- Memory and Cognition: An animal study performed at Johns Hopkins University found that CoQ10 supplementation improves learning and memory.27 PQQ has been shown to protect memory and cognition in both aging animals and humans.28,29
- Bronchial health: Researchers in Texas found CoQ10 promotes bronchial health.30
- Gum health: CoQ10 can improve gum and oral health.31
- Clear-headed comfort: In one study, more than 6 out of 10 patients treated with CoQ10 daily reported feeling more clear-headed comfort.32
- Oxidative stress: CoQ10 is a powerful antioxidant, eliminating the free radicals that can cause damage to cell membranes and mitochondria.33
- Skin care: A German study showed that CoQ10 can help reduce the appearance of wrinkles and help protect skin from the damaging effects of too much exposure to sunlight.34
Put the Secret of "Eternal Youth" in Your Hands Today
I tell my patients the most important thing I help them do is extend their "health span." That’s what I call the length of time you can live in this world free of disease, and with all your youthful abilities still intact.
And since the early 1990s, all we had to protect your mitochondria and extend your health span was CoQ10. And that was the weak version. Then in 2006, I introduced much of the world to the new, high-powered CoQ10 that’s up to 8 TIMES more absorbable.
But now we’ve moved into new territory. You might call it, "the realm of the gods."
Because that’s certainly how it FEELS.
Imagine how you’re going to feel with this new, more powerful formula. I’m not sure there are words to describe it.
When you combine these three miraculous nutrients, you’re not simply protecting your mitochondria and ensuring your cells have enough fuel to make energy…
…you’re MULTIPLYING the number of power generators in each of your cells and experiencing superhuman levels of energy.
You’re taking a giant leap toward "eternal youth." As you saw in the experiment above, the mice that had the strongest mitochondria showed no signs of aging. Even when they were the equivalent of 80-year-old people.
And now you have the opportunity to go even further by using Ultra Accel II to make you feel stronger, more resilient and more potent than we ever thought possible.
Maybe even more powerful than nature intended!
We know from years of research that AMPK, CoQ10 and PQQ have a direct effect on human metabolism and physiology. I’ve seen the evidence of clinical tests firsthand. And I’ve seen the effects in my patients.
May I share a secret with you? I intend to have the energy and vitality of a teenager well into my 60s, 70s, and even my 80s! That’s my goal, anyway. And it’s the whole point of anti-aging medicine: to retain the power of youth well into our old age.
That’s why Ultra Accel II is the one Primal Force formula I make sure I take every day… even when I travel! And I plan to take it every day for as long as I live. You should, too.
And now I’ve made taking Ultra Accel II more convenient and affordable than ever…
Try Ultra Accel II Now and Save Big!
For a limited time only, I’m offering a special discount on my new Ultra Accel II formula:
Thousands of people have already spent over $69.95 per bottle for my Ultra Accel supercharged CoQ10 and PQQ cellular energy formula.
Now I’m offering an even lower price for my NEW and IMPROVED Ultra Accel II formula with gynostemma extract for superhuman levels of energy!
Here’s the first way to save.
When you take advantage of my Introductory Limited-Time Trial Offer, you’ll save $14 off our normal price of $69.95.
It comes out to less than $2 per day.
That’s a great deal…
But you can save even more with my VIP SPECIAL INTRODUCTORY OFFER.
I want you to have an easy, stress-free opportunity to try this breakthrough formula that generates renewed energy at the cellular level. Energy you can actually feel.
With my VIP Special Introductory Offer, you immediately save $83.95 and get 2 bottles of Ultra Accel II for only $55.96.
I’ll even include FREE Shipping.
That means you’re getting 2 bottles for less than most people pay for one!
This is a one-shot deal, and I can’t guarantee it will be available forever.
So let me hear from you today.
Take Ultra Accel II TODAY 100% Risk-Free!
When your shipment of Ultra Accel II arrives, open a bottle and take one softgel. Do that every single day. Then, in a week, look in a mirror and take a quick self-assessment.
I bet you’ll notice some subtle — and maybe not so subtle — changes. Most obviously, you’ll have more energy. You may feel better. When you step on the scale, you might see that you’ve lost a pound or two. But whatever the results, you are the final judge…
If for any reason… or for no reason at all… you do not want to continue taking Ultra Accel II, just return the unused portion — or even the empty bottles — to me within 90 days. I’ll cheerfully give you a full and prompt refund of every penny paid, without question or quibble. That way, you risk nothing.
So what are you waiting for?
You have absolutely nothing to lose — and many years, even decades, of healthy living to gain.
To Your Good Health,
Al Sears, MD, CNS
P.S. I urge you to hurry. Since I released Ultra Accel II, we keep selling out of our supply and I have to call our plant with instructions to manufacture more. That can take a week or two, depending on how busy they are. So, to be sure of getting Ultra Accel II without delay, please send your order now.
Yes, Dr. Sears! I want to combine the new Gynostemma pentaphyllum with PQQ with CoQ10 for increased energy, improved metabolism, weight loss, cell protection, and better cardiovascular health. Please send me your new Ultra Accel II today!
VIP SPECIAL INTRODUCTORY OFFER — BUY ONE, GET THE SECOND FREE!
Save $83.95 And Get FREE Shipping!
Save 60% when you order 2 bottles of Ultra Accel II for just $55.96. And you’ll also receive Free Shipping.
Remember, if you’re not satisfied you can get a prompt refund of every dollar you paid within 90 days. That way, you risk nothing.
You’ll get a 1-month supply of Ultra Accel II for $55.96 plus shipping and handling.
Meet Al Sears, MD
Uniquely Qualified to Keep You Healthier for Life
Al Sears, MD is America’s #1 anti-aging doctor. He’s made it his life’s work to challenge conventional medical beliefs and bring his patients the latest breakthroughs in natural cures and remedies to diseases once thought to be “incurable.”
Dr. Sears takes a fresh, novel approach to patient health and wellness. Our environment has changed for the worse — and it’s affecting your health. He helps patients escape accelerated aging caused by modern toxins, chemicals and other hormonal threats you unknowingly face every day.
Every year, he travels over 20,000 miles to the most remote regions of the world searching for natural healing secrets unknown or ignored by mainstream medicine.
Since 1999, Dr. Sears has published 35 books and reports on health and wellness. He has millions of loyal readers spread over 163 countries.
Today he writes and publishes two monthly e-Newsletters, Confidential Cures and Anti-Aging Confidential for Women, and a daily email broadcast, Doctor’s House Call, with more than 500,000 subscribers. He has also appeared on more than 50 national radio programs, ABC News, CNN and ESPN.
Dr. Sears was one of the first to be board-certified by the American Academy of Anti-Aging Medicine (A4M). More than 25,000 patients travel from all around the world to visit him at the Sears Institute for Anti-Aging Medicine in beautiful Royal Palm Beach, Florida.
Recently, Dr. Sears proved you can affect the way you age by controlling the length of your telomeres. He made history as the first MD to introduce the Nobel prize-winning, anti-aging breakthrough of our time, telomere DNA therapy, to the general public. And now he’s working with the leading scientists in the field of telomere biology to further define how this incredible technology will shape the future of anti-aging medicine.
HERE’S WHAT INDUSTRY EXPERTS ARE SAYING ABOUT DR. SEARS
“Dr. Sears blows away the conventional medical wisdom…”
— Ronald Klatz, MD, DO, Founder and President, American Academy of Anti-Aging Medicine
“Dr. Sears has distinguished himself as a leader in the area of Anti-Aging Medicine and recently in cell and telomere biology…”
— Frederic J. Vagnini, MD, FACS, Medical Director of the Heart, Diabetes and Weight Loss Centers of NY
“Dr. Sears masterfully explains how we can flip the switches that allow access to the store of human vitality that resides within each one of us. We understood how to do this when we were young and now Dr. Sears gives us the evidence-based means to tap into our potency, strength, and stamina with intention.”
— Paul L. Hester, MD, MBA
“Dr. Al Sears really gets it. What a refreshing breath of fresh air…”
— Jonny Bowden, author, Living the Low Carb Life: From Atkins to the Zone Choosing the Diet That’s Right for You
1 W. Kim et al.: “Steaming of Ginseng at High Temperature Enhances Biological Activity,” J. Nat. Prod., vol. 63, No. 12, 2000, pp. 1702-1704.
2 Bordone, L., Guarente, L. Calorie restriction, SIRT1 and metabolism: understanding longevity. Nat Rev Mol Cell Biol. 2005;6:298–305.
3 Stenesen D, Suh JM, Seo J, et al. Adenosine nucleotide biosynthesis and AMPK regulate adult life span and mediate the longevity benefit of caloric restriction in flies. Cell Metab. 2013 Jan 8;17(1):101-12.
4 Greer E.L., Dowlatshahi D., Banko M.R., Villen J., Hoang K., Blanchard D. An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans. Curr. Biol.2007;17:1646–1656.
5 M. Ulgherait, A. Rana, M. Rera, J. Graniel, D.W. Walker. AMPK modulates tissue and organismal aging in a non-cell-autonomous manner. Cell Rep., 8 (2014), pp. 1767–1780.
6 Ruderman, N.B., Carling, D., Prentki, M., Cacicedo, J.M. AMPK, insulin resistance, and the metabolic syndrome. J Clin Invest. 2013;123:2764–2772.
7 Andersson U, Berger K, Hogberg A, Landin-Olsson M, Holm C. Effects of rose hip intake on risk markers of type 2 diabetes and cardiovascular disease: a randomized, double-blind, cross-over investigation in obese persons. Eur J Clin Nutr. 2012 May;66(5):585-90.
8 Wu SB, Wu YT, Wu TP, Wei YH. Role of AMPK-mediated adaptive responses in human cells with mitochondrial dysfunction to oxidative stress. Biochim Biophys Acta. 2014 Apr;1840(4):1331-44.
9 Towler MC, Hardie DG. AMP-activated protein kinase in metabolic control and insulin signaling. Circ Res. 2007 Feb 16;100(3):328-41.
10 Foram N. Ashar, Anna Moes et al. Association of mitochondrial DNA levels with frailty and all-cause mortality. Journal of Molecular Medicine. February 2015, Volume 93, Issue 2, pp 177-186.
11 Salminen A, Kaarniranta K. AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network. Ageing Res Rev. 2012 Apr;11(2):230-41.
12 Bruce A, Johnson A, Lewis J, Raff M, Roberts K, Walter P. “Molecular Biology of the Cell.” New York, NY: Garland Publishing, Inc.;1994.
13 Voet D, Voet JG, Pratt CW. “Fundamentals of Biochemistry: Life at the Molecular Level. 2nd ed.” New Jersey: John Wiley and Sons, Inc.; 2006:547.
14 Pike RL, Brown M. “Nutrition: An Integrated Approach.” New York, NY: Prentice-Hall; 1984:450-84. Stites, T. et al. “Pyrroloquinoline Quinone Modulates Mitochondrial Quantity and Function in Mice.” J. Nutr. February 2006 vol. 136 no. 2 390-396.
15 Stites, T. et al. “Pyrroloquinoline Quinone Modulates Mitochondrial Quantity and Function in Mice.” J. Nutr. February 2006 vol. 136 no. 2 390-396.
16 Yamaguchi K, Sasano A, Urakami T, Tsuji T, Kondo K. “Stimulation of nerve growth factor production by pyrroloquinoline quinone and its derivatives in vitro and in vivo.” Biosci Biotechnol Biochem. 1993 Jul;57(7):1231-3.
17 Murase K, Hattori A, Kohno M, Hayashi K. “Stimulation of nerve growth factor synthesis/secretion in mouse astroglial cells by coenzymes.” Biochem Mol Biol Int. 1993 Jul;30(4):615-21.
18 Bishop A, Gallop PM, Karnovsky ML. “Pyrroloquinoline quinone: a novel vitamin?” Nutr Rev. 1998 Oct;56(10):287-93.
19 Hara H, Hiramatsu H, Adachi T. “Pyrroloquinoline quinone is a potent neuroprotective nutrient against 6-hydroxydopamine- induced neurotoxicity.” Neurochem Res. 2007 Mar;32(3):489-95.
20 Baggio E, Gandini R, Plancher AC, Passeri M, Carmosino G. “Italian multicenter study on the safety and efficacy of coenzyme Q10 as adjunctive therapy in heart….” Mol Aspects Med. 1994;15 Suppl:s287-94.
21 Singh R, Wander G, Rastogi A, Shukla P, Mittal A, Sharma J, Mehrotra S, Kapoor R, Chopra R. “Randomized, double-blind placebo- controlled trial of coenzyme Q10 in patients …” Cardiovasc Drugs Ther. 1998;12(4):347-53.
22 Tao R, Karliner JS, Simonis U, et al. Pyrroloquinoline quinone preserves mitochondrial function and prevents oxidative injury in adult rat cardiac myocytes. Biochem Biophys Res Commun. 2007;363:257–262.
23 Hodgson JM, Watts GF, Playford DA, Burke V, Croft KD. “Coenzyme Q10 improves blood … and glycemic control in a controlled trial in subjects…” Eur J Clin Nutr. 2002;56(11):1137-42.
24 O’Neill HM, Maarbjerg SJ, Crane JD, et al. AMP-activated protein kinase (AMPK) beta1beta2 muscle null mice reveal an essential role for AMPK in maintaining mitochondrial content and glucose uptake during exercise. Proc Natl Acad Sci USA. 2011 Sep 20;108(38):16092-7.
25 Qu J, Kaufman Y, Washington I. “Coenzyme Q10 in the human retina.” Invest Ophthalmol Vis Sci. 2009;50(4):1814-8.
26 Towler MC, Hardie DG. AMP-activated protein kinase in metabolic control and insulin signaling. Circ Res. 2007 Feb 16;100(3):328-41.
27 Schilling G, Coonfield M, Ross C, Borchelt D. “Coenzyme Q10 and remacemide hydrochloride ameliorate motor deficits in a … transgenic mouse model.” Neurosci Lett. 2001;315(3):149-53.
28 Takatsu H, Owada K, Abe K, Nakano M, Urano S. Effect of vitamin E on learning and memory deficit in aged rats. J Nutr Sci Vitaminol (Tokyo). 2009;55(5):389-93.
29 Nakano M, Ubukata K, Yamamoto T, Yamaguchi H. Effect of pyrroloquinoline quinone (PQQ) on mental status of middle-aged and elderly persons. FOOD Style 21. 2009;13(7):50-3.
30 Gazdík F, Gvozdjáková A, Nádvorníková R, Repická L, Jahnová E, Kucharská J, Piják MR, Gazdíková K. “Decreased levels of coenzyme Q(10) in patients with bronchial asthma.” Allergy. 2002 Sep;57(9):811-4.
31 Hanioka T, Tanaka M, Ojima M, Shizukuishi S, Folkers K. “Effect of topical application of coenzyme Q10 on adult periodontitis.” Mol Aspects Med. 1994;15 Suppl:s241-8.
32 Ye CQ, Folkers K, Tamagawa H, Pfeiffer C. “A modified determination of coenzyme Q10 in human blood and CoQ10 blood levels in diverse patients with allergies.” Biofactors. 1988 Dec;1(4):303-6.
33 Hoppe U, et. al. “Coenzyme Q10, a cutaneous antioxidant and energizer.” Biofactors. 1999;9(2-4):371-8.
34 Blasi MA, Bovina C, Carella G, Genova ML, Jansen AM, Lenaz G, Brancato R. “Does coenzyme Q10 play a role in opposing oxidative stress in patients …?” Ophthalmologica. 2001;215(1):51-4.
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Results may vary from person to person. No individual result should be seen as typical.
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Al Sears, M.D., is a practicing physician with extensive experience in the fields of complementary and natural healthcare. The recommendation and materials on this site represent his opinion based on his years of practicing medicine. Any recommendations are not intended to replace the advice of your physician. You are encouraged to seek advice from a competent medical professional regarding the applicability of any recommendations with regard to your symptoms or condition. It is important that you do not reduce, change or discontinue any medication or treatment without consulting your physician first.